Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists
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چکیده
منابع مشابه
Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists.
In vitro assays using liver subcellular fractions or suspended hepatocytes for characterizing the metabolism of drug candidates play an integral role in the optimization strategy employed by medicinal chemists. However, conventional in vitro assays have limitations in their ability to predict clearance and generate metabolites for low-turnover (slowly metabolized) drug molecules. Due to a rapid...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2015
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.115.066431